DIB 1.0g Vaginal Delivery System

Administration

Vaginal use. 1.0 g of progesterone (1 device) per animal for 7-9 days (depending on indication).

The following protocols could be used:

For synchronisation of oestrus (including synchronisation of oestrus of donor and recipient animals for embryo transfer

• Insert one device into the vagina for 7 days
• Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal
• In animals that respond to treatment the onset of oestrus generally occurs within 1-3 days after removal of the insert. Cows should be inseminated within 12 hours of first observed oestrus.

For the induction and synchronisation of oestrus for Fixed Time Artificial Insemination (FTAI):

In cycling cows and heifers

• Insert one device into the vagina for 7 days
• Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal
• FTAI 56 hours after removal of the device.

In cycling and non-cycling cows and heifers

• Insert one device into the vagina for 7- 8 days
• Inject a dose of GnRH or analogue at device insertion
• Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal
• FTAI 56 hours after removal of the device, or- Inject GnRH or analogue 36 hours after device removal and FTAI 16 to 20 hours later.

In non-cycling cows

• Insert one device into the vagina for 9 days
• Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal
• Inject eCG at device removal
• FTAI 56 hours after removal of the device, or inseminate within 12 hours following first observed oestrus behaviour.

Administration

The device specific applicator should be used for administration, following the procedure described below:

1. Ensure that the applicator is clean and disinfected using a non-irritant antiseptic solution before use.
2. Wearing sterile disposable plastic gloves, fold the arms of the device and load into the applicator. The arms of the device should protrude slightly from the end of the applicator. Care should be taken to avoid unnecessary or prolonged handling of the product to minimise transfer of the active substance to the operator's gloves.
3. Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4. Lift the tail and clean the vulva and perineum.
5. Gently insert the applicator into the vagina, first in a vertical direction and then horizontally until some resistance is encountered.
6. Make sure the removal string is free, press the handle of the applicator and allow the barrel to move back towards the handle. This releases the arms of the device, which will then retain the device in the anterior vagina.
7. With the device correctly positioned, withdraw the applicator, leaving the removal string hanging from the vulva.
8. The applicator should be cleaned and disinfected before being used on another animal.

Removal

The device may be removed by gently pulling on the string. On occasions the string may not be visible from the outside of the animal, in such cases it may be located in the posterior vagina using a gloved finger. Withdrawal of the device should not require force. If any resistance is encountered a gloved hand should be used to ease removal.

If there is any difficulty in removal from the animal beyond that itemised above veterinary advice must be sought.

The device is intended for single use only.